Fatal flecainide intoxication.
نویسندگان
چکیده
Two fatalities resulting from suicidal ingestion of flecainide are described. The decedents, ages 33 and 15, were otherwise healthy; both took their mothers' medications. In one case, from electrocardiographic data, there was found a high-grade conduction block with idioventricular rhythm. Blood and tissue samples from autopsy were analyzed for flecainide by gas chromatography/nitrogen-phosphorous detection and gas chromatography/mass spectrometry. Blood concentrations of 93.7 and 100 mg/L flecainide were found.
منابع مشابه
Fatal flecainide intoxication
Flecainide acetate is a potent class IC antiarrhythmic agent used mainly for the treatment of supraventricular arrhythmias. Acute overdose of this drug is rare but frequently fatal. The clinical course of a patient that ingested a large quantity of flecainide as a suicide attempt is described and current therapeutic strategies discussed. (JAccid Emerg Med 1998;15:423-425)
متن کاملAnalysis of flecainide and two metabolites in biological specimens by HPLC: application to a fatal intoxication.
A few days after her admittance to a hospital for a suicide attempt with benzodiazepines, a 15-year-old girl was found dead in bed. At autopsy, no specific anatomo-pathologic cause of death was identified. Systematic toxicological analysis (HPLC-DAD, GC-NPD, and GC-MS) of postmortem blood and urine revealed the presence of high concentrations of flecainide and its two major metabolites. Flecain...
متن کاملBroad complex rhythm with a salty taste
The ECG (Fig. 1 in the question) shows an extremely broad QRS complex rhythm (QRS duration of 220ms) with a heart rate of 95 beats/min and a left axis deviation. The differential diagnosis of a broad QRS complex rhythm (without tachycardia) is extensive, including bundle branch block (either rate dependent or fixed), hyperkalaemia, pre-excitation, ventricular pacing, (accelerated) idioventricul...
متن کاملFlecainide-Induced Torsade de Pointes Successfully Treated with Intensive Pharmacological Therapy
Flecainide is a class IC anti-arrhythmic drug that acts by blocking the fast inward sodium channels during phase 0 of action potential. It is used to treat both supraventricular and ventricular arrhythmias. However, flecainide is also a pro-arrhythmic agent, and overdose may cause nausea, vomiting, hypotension, bradycardia, varying degrees of atrioventricular block, tachyarrhythmias (such as to...
متن کاملA case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate.
BACKGROUND Flecainide is a class IC antidysrhythmic primarily indicated for ventricular dysrhythmias and supraventricular tachycardia (SVT). Class IC antidysrhythmic overdose has a reported mortality of 22%, and death results from dysrhythmias and cardiovascular collapse. We report a near-fatal flecainide overdose in an 18-day-old treated successfully with sodium bicarbonate. CASE REPORT An 1...
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ورودعنوان ژورنال:
- Journal of analytical toxicology
دوره 17 7 شماره
صفحات -
تاریخ انتشار 1993